Immunodeficiency disorders are conditions in which one or more components of the immune system fail to function adequately, resulting in increased susceptibility to infections. Primary immunodeficiencies (PIDs) are genetic disorders present from birth that may not manifest clinically until childhood or even adulthood. Common PIDs include Common Variable Immunodeficiency (CVID), selective IgA deficiency, and specific antibody deficiency. Secondary immunodeficiencies are acquired and can result from medications, malnutrition, or other medical conditions.
Common Signs & Symptoms
- Four or more ear infections per year in children
- Two or more serious sinus infections per year
- Two or more pneumonias per year
- Need for intravenous antibiotics to clear infections
- Infections that recur shortly after antibiotics are stopped
- Infections with unusual or opportunistic organisms
- Family history of primary immunodeficiency
How We Diagnose
Immune evaluation at South Bay Allergy includes quantitative immunoglobulin levels (IgG, IgA, IgM, IgE), specific antibody responses to vaccine antigens (e.g., pneumococcal, tetanus), complete blood count with differential to evaluate lymphocyte populations, lymphocyte subset analysis (T cells, B cells, NK cells) when indicated, and complement levels and neutrophil function testing as appropriate.
Treatment Options
Treatment is tailored to the specific immunodeficiency identified. Options may include immunoglobulin replacement therapy (intravenous or subcutaneous IgG) for antibody deficiency disorders, prophylactic antibiotics to prevent recurrent bacterial infections, infection management and vaccination optimization, close follow-up and coordination with hematology, infectious disease, and other specialists, and genetic counseling referral when a heritable condition is identified.
Ready to Schedule?
If you or your child experiences unusually frequent or severe infections, do not wait. Contact South Bay Allergy and Asthma Group for a comprehensive immune system evaluation. Call us at (408) 286-1707 or request an appointment online.